Chronic Illnesses Connected to Mast Cell Activation Syndrome (MCAS) and Mast Cell Disorder

Mast Cell Activation Syndrome (MCAS) and Mast Cell Disorder (mastocytosis) are related conditions that cause dysfunction of mast cells, but they differ in several key aspects. While both conditions involve mast cell dysfunction, MCAS is

1. the abnormal activation of mast cells, which releases various mediators and results in symptoms such as flushing, itching, abdominal pain, and fatigue.
2. In contrast, Mast Cell Disorder is a rare disorder characterized by the abnormal proliferation of mast cells in various organs, leading to the formation of mast cell tumors and the release of excessive mediators.

What Causes Mast Cell Disorder and Mast Cell Activation Syndrome?

Mast Cell Activation Syndrome can occur in healthy people as a response to stress, infections, certain medications, and even mosquito bites. MCAS can be diagnosed based on clinical symptoms, elevated levels of mast cell mediators, and positive response to treatment. Mastocytosis is diagnosed through a combination of clinical findings.

Genetic mutations play a role in the development of Mast Cell Disorder. Mutations in genes such as KIT and C-KIT have been associated with an increased risk of developing this condition. Environmental factors such as exposure to certain chemicals and toxins are linked to the development of Mast Cell Disorder. As described here, specific syndromes, infections, and autoimmune conditions may trigger the onset of this particular disorder. While conventional medical treatments for mast cell disorder focus on managing symptoms with medications, many individuals find relief through integrative medicine approaches.

Symptoms of Mast Cell Activation Syndrome

• Hives, flushing, itching
• Abdominal pain, diarrhea, nausea
• Wheezing, shortness of breath, coughing
• Rapid heart rate, low blood pressure
• Headache, dizziness, brain fog
• Joint pain, muscle pain, weakness
• Fatigue and malaise
• Allergic reactions to various triggers
• Fever, weight loss, night sweats
• Anxiety, depression

Symptoms of Mast Cell Disorder

• Flushing or redness of the skin
• Itching or hives
• Abdominal pain or cramping
• Nausea or vomiting
• Diarrhea
• Difficulty breathing or wheezing
• Rapid heart rate
• Low blood pressure
• Fatigue or weakness
• Headache or migraines
• Joint pain or swelling
• Memory or concentration problems
• Anxiety or depression
• Sleep disturbances

Coexisting Conditions and Mast Cell Disorder

While Mast Cell dysfunctions can occur independently, it is not uncommon for individuals to have coexisting conditions that can further complicate their health. These coexisting conditions can vary, but several are commonly associated with Mast Cell Disorder.

1. One common coexisting condition is Ehlers-Danlos Syndrome (EDS), a group of genetic disorders that affect the connective tissues in the body. EDS can cause joint hypermobility, skin fragility, and other symptoms that can exacerbate the symptoms of Mast Cell Disorder. The combination of these two conditions can lead to increased pain, fatigue, and a higher risk of injury.
2. Another coexisting condition often seen in individuals with Mast Cell Disorder is Postural Orthostatic Tachycardia Syndrome (POTS). POTS is a condition that affects the autonomic nervous system, causing an abnormal increase in heart rate upon standing up. This can lead to dizziness, lightheadedness, and fainting spells. When POTS is present alongside Mast Cell Disorder, it can further contribute to the overall dysfunction of the autonomic nervous system and worsen symptoms.
3. Many individuals with Mast Cell Disorder also have gastrointestinal issues such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). These conditions can cause abdominal pain, bloating, diarrhea, and other digestive symptoms. Gastrointestinal issues can become even more severe and difficult to manage when combined with heightened mast cell activity.

Holistic Treatment for Mast Cell Conditions

Given that many illnesses are associated with Mast Cell Disorder, it is critical to find the underlying causes. Doctors at Restoration Healthcare have a great deal of experience diagnosing Mast Cell Disorder and MCAS and any related complex chronic illnesses through a combination of medical history, diagnostic tests, physical examination, and laboratory tests.

1. A patient’s medical history provides vital information to help doctors establish patterns, exposures, and immune reactions that help lead to a diagnosis.
2. A physical examination will check for any visible signs of mast cell activation, such as skin rashes or swelling.
3. Laboratory tests measure the levels of certain chemicals in the blood and urine, such as tryptase and histamine, which can indicate mast cell activation.

While integrative medicine approaches can be beneficial for managing mast cell dysfunction, consulting a healthcare professional knowledgeable in this area is essential. They can provide personalized recommendations based on an individual’s needs and medical history. By combining conventional medical treatments with integrative medicine, individuals with mast cell disorder can take a comprehensive and holistic approach to managing their condition and improving their quality of life.

The integrative medical team at Restoration Healthcare will develop a personalized treatment plan to address all related conditions. Treatment may include medication to control acute symptoms, IV infusion therapies, nutritional support to help avoid triggers, dietary supplements, and lifestyle modifications.

Avoiding Common Triggers of Mast Cell Activation

One key aspect of managing mast cell disorder through integrative medicine is identifying and avoiding triggers that activate mast cells. This may include certain foods, stress, and inflammation.

By following a low-histamine diet and eliminating trigger foods, individuals with mast cell disorder may experience reduced symptoms and improved overall well-being.

In addition to dietary modifications, stress management techniques can be crucial in managing mast cell disorder. Stress can trigger mast cell activation and worsen symptoms. Therefore, incorporating stress-reducing practices such as meditation, yoga, and deep breathing exercises can help to calm the body’s stress response and reduce mast cell activation.

Targeted supplements may be prescribed to support mast cell stabilization and reduce inflammation. Natural antihistamines, such as quercetin and bromelain, have been found to inhibit mast cell activation and reduce histamine release. Additionally, supplements like vitamin C and omega-3 fatty acids have anti-inflammatory properties that can help alleviate symptoms associated with mast cell disorder.

Exposure to specific allergens can trigger mast cell disorders, including environmental allergens such as pollen, dust mites, pet dander, and food allergens like shellfish, nuts, and dairy products. When individuals with mast cell disorder come into contact with these allergens, it can lead to an overreaction of the immune system and the release of excessive amounts of histamine.

Activities that involve physical exertion, such as exercise or even simply walking up a flight of stairs, can cause mast cells to become activated and release histamine. Similarly, emotional stress or anxiety can also trigger mast cell activation. Individuals with mast cell disorder must be mindful of their physical and emotional well-being to minimize the risk of triggering symptoms.

In addition, certain medications and environmental factors can also act as triggers for mast cell disorder. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, have been known to cause mast cell activation in some individuals. Other triggers include temperature changes, exposure to chemicals or strong odors, and infections.

In conclusion, mast cell dysfunction can be triggered by various factors, including coexisting conditions, allergens, physical exertion or stress, medications, and environmental factors. Individuals with mast cell disorder and MCAS should seek care from experienced physicians to identify underlying causes and find the best course of treatment.

If you live in Orange County or Los Angeles and are looking for support for a complex chronic illness, please inquire about becoming a new patient at our clinic.